Some may have more than one recipe for the same result. These are all the known Horadric Cube recipes. Make sure you know what you're making before you combine! If you don't have the right items, it simply won't do anything. To use the Horadric Cube, place the correct group of materials inside the Cube and click the Transmute button at the bottom. For this reason, some players short on stash space will use the Horadric Cube as temporary storage, tossing items onto the ground while they do their Transmutes. It takes up a 2x2 space but has 12 slots inside. The Horadric Cube can either be carried in your personal inventory or in your stash (most people keep it in the stash). Since it's available on Normal mode, you will get the Cube early. It's located in the Halls of the Dead, guarded by Bloodwitch the Wild. You will acquire the Horadric Cube as part of your questing through Act II. It's even used to create the item required to open the famed Secret Cow Level! It's also involved in some quest lines, as it's needed to create items that open doors to new adventuring realms.

The Horadric Cube is an ancient item of Horadric design, used to transmute items such as gear, runes, gems, potions, and scrolls into more powerful versions of the original, add sockets to existing armor, and create specific magical items.